J. Michael McBride–Organic Chemistry–Yale University Online Course–Videos

Posted on March 24, 2010. Filed under: Blogroll, Chemistry, Communications, Education, Links, media, Science | Tags: , |

 

Freshman Organic Chemistry with J. Michael McBride

This is the first semester in a two-semester introductory course focused on current theories of structure and mechanism in organic chemistry, their historical development, and their basis in experimental observation. The course is open to freshmen with excellent preparation in chemistry and physics, and it aims to develop both taste for original science and intellectual skills necessary for creative research.

Syllabus

Professor:

J. Michael McBride, Richard M. Colgate Professor of Chemistry, Yale University

Description:

This is the first semester in a two-semester introductory course focused on current theories of structure and mechanism in organic chemistry, their historical development, and their basis in experimental observation. The course is open to freshmen with excellent preparation in chemistry and physics, and it aims to develop both taste for original science and intellectual skills necessary for creative research.

Texts:

Reading assignments, problem sets, PowerPoint presentations, and other resources for this course can be accessed from Professor McBride’s on-campus course website, which was developed for his Fall 2008 students. Please see Resources section for each individual lecture.

Requirements:

The course grade is based on a 650-point system: 100 points for each of the three hour-long midterm examinations, 300 points for the three-hour final examination, and 50 points for participation in the course Wiki. In borderline cases, faithfulness in completing and submitting problem sets will be considered.

Grading:

Midterm Examination 1: 100 points
Midterm Examination 2: 100 points

CHEM 125: Freshman Organic Chemistry

Class Sessions

Click session titles below to access audio, video, and course materials.

1. How Do You Know?
2. Force Laws, Lewis Structures and Resonance
3. Double Minima, Earnshaw’s Theorem, and Plum-Puddings
4. Coping with Smallness and Scanning Probe Microscopy
5. X-Ray Diffraction
6. Seeing Bonds by Electron Difference Density
7. Quantum Mechanical Kinetic Energy
8. One-Dimensional Wave Functions
9. Chladni Figures and One-Electron Atoms
10. Reality and the Orbital Approximation
Midterm Exam 1
11. Orbital Correction and Plum-Pudding Molecules
12. Overlap and Atom-Pair Bonds
13. Overlap and Energy-Match
14. Checking Hybridization Theory with XH3
15. Chemical Reactivity: SOMO, HOMO, and LUMO
16. Recognizing Functional Groups
17. Reaction Analogies and Carbonyl Reactivity
18. Amide, Carboxylic Acid and Alkyl Lithium
19. Oxygen and the Chemical Revolution (Beginning to 1789)
Midterm Exam 2
20. Rise of the Atomic Theory (1790-1805)
21. Berzelius to Liebig and Wöhler (1805-1832)
22. Radical and Type Theories (1832-1850)
23. Valence Theory and Constitutional Structure (1858)
24. Determining Chemical Structure by Isomer Counting (1869)
25. Models in 3D Space (1869-1877); Optical Isomers
26. Van’t Hoff’s Tetrahedral Carbon and Chirality
27. Communicating Molecular Structure in Diagrams and Words
28. Stereochemical Nomenclature; Racemization and Resolution
29. Preparing Single Enantiomers and the Mechanism of Optical Rotation
Midterm Exam 3
30. Esomeprazole as an Example of Drug Testing and Usage
31. Preparing Single Enantiomers and Conformational Energy
32. Stereotopicity and Baeyer Strain Theory
33. Conformational Energy and Molecular Mechanics
34. Sharpless Oxidation Catalysts and the Conformation of Cycloalkanes
35. Understanding Molecular Structure and Energy through Standard Bonds
36. Bond Energies, the Boltzmann Factor and Entropy
37. Potential Energy Surfaces, Transition State Theory and Reaction Mechanism
Final Exam

 

1. How Do You Know?

2. Force Laws, Lewis Structures and Resonance

3. Double Minima, Earnshaw’s Theorem and Plum-Puddings

4. Coping with Smallness and Scanning Probe Microscopy

5. X-Ray Diffraction

6. Seeing Bonds by Electron Difference Density

7. Quantum Mechanical Kinetic Energy

8. One-Dimensional Wave Functions

9. Chladni Figures and One-Electron Atoms

10. Reality and the Orbital Approximation

11. Orbital Correction and Plum-Pudding Molecules

12. Overlap and Atom-Pair Bonds

13. Overlap and Energy-Match

14. Checking Hybridization Theory with XH_3

15. Chemical Reactivity: SOMO, HOMO, and LUMO

16. Recognizing Functional Groups

17. Reaction Analogies and Carbonyl Reactivity

18. Amide, Carboxylic Acid and Alkyl Lithium

19. Oxygen and the Chemical Revolution (Beginning to 1789)

20. Rise of the Atomic Theory (1790-1805)

21. Berzelius to Liebig and Wöhler (1805-1832)

22. Radical and Type Theories (1832-1850)

23. Valence Theory and Constitutional Structure (1858)

24. Determining Chemical Structure by Isomer Counting (1869)

25. Models in 3D Space (1869-1877); Optical Isomers

26. Van’t Hoff’s Tetrahedral Carbon and Chirality

27. Communicating Molecular Structure in Diagrams and Words

28. Stereochemical Nomenclature; Racemization and Resolution

29. Preparing Single Enantiomers and the Mechanism of Optical Rotation

30. Esomeprazole as an Example of Drug Testing and Usage

31. Preparing Single Enantiomers and Conformational Energy

32. Stereotopicity and Baeyer Strain Theory

33. Conformational Energy and Molecular Mechanics

34. Sharpless Oxidation Catalysts and the Conformation of Cycloalkanes

35. Understanding Molecular Structure and Energy through Standard Bonds

36. Bond Energies, the Boltzmann Factor and Entropy

37. Potential Energy Surfaces, Transition State Theory and Reaction Mechanism

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